Table 1 MR results of the causal effect of interleukin on sarcopenia traits
Exposure | Methods | ALM | HGS (left) | HGS (right) | Walking pace | ||||
|---|---|---|---|---|---|---|---|---|---|
β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | ||
Main IL-6 (n SNPs = 2) | IVW | -0.045 (0.095) | 0.63 | -0.023 (0.065) | 0.72 | -0.026 (0.066) | 0.70 | -0.017 (0.012) | 0.15 |
WM | |||||||||
MR-Egger | |||||||||
eQTL IL-6 (n SNPs = 3) | IVW | 0.006 (0.013) | 0.67 | -0.020 (0.012) | 0.11 | -0.027 (0.015) | 0.07 | -0.001 (0.010) | 0.99 |
WM | 0.007 (0.014) | 0.63 | -0.022 (0.014) | 0.12 | -0.032 (0.014) | 0.02 | 0.003 (0.012) | 0.81 | |
MR-Egger | -0.019 (0.082) | 0.86 | -0.021 (0.087) | 0.85 | -0.025 (0.110) | 0.92 | -0.022 (0.055) | 0.75 | |
Main IL-6R (n SNPs = 7) | IVW | -0.007 (0.004) | 0.10 | -0.013 (0.004) | < 0.001 | -0.011 (0.004) | < 0.001 | -0.005 (0.003) | 0.08 |
WM | -0.007 (0.005) | 0.15 | -0.014 (0.004) | < 0.001 | -0.013 (0.004) | 0.01 | -0.003 (0.004) | 0.47 | |
MR-Egger | -0.004 (0.009) | 0.70 | -0.002 (0.007) | 0.82 | -0.002 (0.008) | 0.85 | -0.005 (0.006) | 0.48 | |
eQTL IL-6R (n SNPs = 8) | IVW | -0.002 (0.008) | 0.05 | -0.029 (0.007) | < 0.001 | -0.021 (0.008) | 0.005 | 0.002 (0.009) | 0.79 |
WM | -0.019 (0.010) | 0.05 | -0.026 (0.010) | 0.009 | -0.012 (0.010) | 0.20 | 0.007 (0.009) | 0.41 | |
MR-Egger | -0.001 (0.026) | 0.96 | -0.034 (0.026) | 0.82 | -0.026 (0.027) | 0.36 | -0.011 (0.032) | 0.75 |