Table 2 Assessment of pleiotropy and heterogeneity in the causal association between interleukin and sarcopenia traits
Exposure | Outcome | Cochran Q | MR-Egger | ||
|---|---|---|---|---|---|
Q value | P | Intercept | P | ||
Main IL-6R | ALM | 6.721 | 0.24 | 0.001 | 0.70 |
HSG (left) | 8.679 | 0.12 | -0.003 | 0.21 | |
HSG (right) | 7.515 | 0.19 | -0.004 | 0.10 | |
Walking pace | 5.428 | 0.37 | -0.001 | 0.98 | |
eQTL IL-6 | ALM | 1.500 | 0.47 | 0.003 | 0.81 |
HSG (left) | 1.781 | 0.41 | 0.001 | 0.99 | |
HSG (right) | 2.886 | 0.24 | -0.001 | 0.92 | |
Walking pace | 0.626 | 0.73 | 0.002 | 0.75 | |
eQTL IL-6R | ALM | 6.238 | 0.51 | -0.002 | 0.59 |
HSG (left) | 6.947 | 0.43 | 0.001 | 0.85 | |
HSG (right) | 7.508 | 0.38 | 0.001 | 0.84 | |
Walking pace | 15.580 | 0.06 | 0.002 | 0.69 |