Fig. 2

Estimated smoothness of baseline eCBs or NAEs on cognitive performance by sex derived from GAMs. The Y-axis depicts the partial effect of baseline 2-AG on baseline global cognition in men (A), baseline OEA on baseline memory in men (B), baseline ratio OEA/AEA on baseline memory in men (C), and baseline ratio OEA/AEA on baseline memory in women (D). The shaded area is the standard-error confidence intervals. Red lines indicate the inflection point for non-linear relationships. Regression coefficients (β) and 95%CI were obtained from linear models for improving the interpretability of linear relationships. The p-value indicates the significance of the smooth term in the GAM