Model | G1 (n = 341) | G2 (n = 771) | G3 (n = 11,479) | G4 (n = 9,241) | G5 (n = 1,647) | Per 0.1mmol/L decrease (iP < 1.16mmol/L) | Per 0.1mmol/L increase (iP ≥ 1.16mmol/L) | Ptrend |
|---|
Sensitivity-1 | 4.76 (3.38, 6.14) | 1.30 (0.36, 2.23) | 0.30 (-0.04, 0.65) | 0 (Ref) | 0.24 (-0.40, 0.88) | 0.56 (0.37, 0.74) | -0.02 (-0.08, 0.04) | < 0.001 |
Sensitivity-2 | 5.42 (4.09, 6.75) | 2.01 (1.10, 2.93) | 0.51 (0.17, 0.86) | 0 (Ref) | 0.29 (-0.36, 0.94) | 0.63 (0.44, 0.82) | -0.03 (-0.08, 0.03) | < 0.001 |
Sensitivity-3 | 3.94 (1.88, 5.99) | 1.39 (0.02, 2.76) | 0.41 (-0.11, 0.94) | 0 (Ref) | 0.09 (-0.87, 1.05) | 0.57 (0.29, 0.85) | -0.04 (-0.12, 0.05) | 0.002 |
Sensitivity-4 | 8.72 (5.96, 11.49) | 1.15 (-0.32, 2.62) | 0.62 (0.09, 1.16) | 0 (Ref) | 0.48 (-0.58, 1.54) | 0.51 (0.23, 0.80) | 0.03 (-0.09, 0.19) | < 0.001 |
Sensitivity-5 | 2.14 (1.57, 2.71) | 1.08 (0.70, 1.45) | 0.1 (-0.04, 0.24) | 0 (Ref) | 0.41 (0.15, 0.66) | 0.34 (0.32, 0.37) | -0.02 (-0.05, 0.02) | < 0.001 |
Sensitivity-6 | 1.88 (0.24, 3.51) | 1.15 (0.20, 2.10) | 0.36 (0.11, 0.71) | 0 (Ref) | 0.21 (-0.44, 0.87) | 0.36 (0.17, 0.56) | 0.05 (-0.07, 0.17) | 0.008 |
- Note:
- 1. Abbreviation: iP, inorganic phosphorus; LOS, length of hospital stay; SD, standard deviation; BMI, body mass index; CCI, Charlson Comorbidity index; eGFR-EPI, estimated glomerular filtration rate calculated by Chronic Kidney Disease Epidemiology Collaboration equation; 25(OH)D, 25 hydroxyvitamin D; Vitamin D3, 25 hydroxyvitamin D3; Vitamin D2, 25 hydroxyvitamin D2; ALT, alanine transferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; γ-GT, gamma glutamyl-transferase; TBIL, total bilirubin; TC, total cholesterol; TG, triglycerides; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; HIV, human immunodeficiency virus; AIDS, acquired immune deficiency syndrome
- 2. The model was adjusted by sex, age (“18–45 y”, “45–65 y” or “≥65 y”), CCI (“0”, “1–2”, or “≥3”), surgery (“no” vs. “yes”), hospital (Ren Ji Hospital vs. Xin Hua hospital), BMI (“<18.5 kg/m2”, “18.5–24 kg/m2”, or “≥24 kg/m2”), serum level of eGFR-EPI (“30–60 ml/min/1.73m2”, “60–90 ml/min/1.73m2”, or “≥90 ml/min/1.73m2”), vitamin D status (“normal” vs. “low”), calcium (“<2.25 mmol/L”, “2.25–2.75 mmol/L”, or “≥2.75 mmol/L”), magnesium (“<0.75 mmol/L” vs. “≥0.75 mmol/L”), sodium (“<135 mmol/L”, “135–145 mmol/L”, or “≥145 mmol/L”), chloride (“<96 mmol/L”, “96–108 mmol/L”, or “≥108 mmol/L”), albumin (“≥35 g/L” vs. “<35 g/L”), pre-albumin (“≥160 mg/dL” vs. “<160 mg/dL”), anemia (“no” vs. “yes”), liver injury (“no” vs. “yes”), dyslipidemia (“no” vs. “yes”), and white blood cell count (“<10 × 109/ml” vs. “≥10 × 109/ml”)
- 3. CCI without terms of HIV infection and AIDS was used to assess the disease severity
- 4. LOS was defined as the time between the measurement of serum phosphate and discharge time or the time of death
- 5. Serum calcium (mmol/L) was calculated as the following equation: serum total calcium (mmol/L) + 0.8×[40-serum albumin (g/L)]
- 6. Low vitamin D status was defined as serum 25(OH)D level < 20 ng/ml or sum of serum vitamin D3 and vitamin D2 level < 20 ng/ml in the absence of 25(OH)D measurement
- 7. Liver injury was determined as any of the following: ALT (≥120 U/L), AST (≥150 U/L), ALP (≥250 U/L), γ-GT (≥100 U/L), or TBIL (≥34.2 μmol/L)
- 8. Dyslipidemia was determined if one of the following criteria was met: serum TC ≥ 6.2 mmol/L, or TG ≥ 2.3 mmol/L, or LDL-C ≥ 4.1 mmol/L, or HDL-C < 1.0 mmol/L
- 9. Anemia was determined if serum level of hemoglobin was less than 120 g/L in males, or less than 110 g/L in females
- 10. Sensitivity-1: excluding patients whose CCI ≥ 3 points (n = 3,070)
- 11. Sensitivity-2: excluding patients whose eGFR-EPI < 60 ml/min/1.73m2 (n = 2,348)
- 12. Sensitivity-3: excluding patients whose body mass index ≥ 24 kg/m2 (n = 9,587) or < 18.5 kg/m2 (n = 1,835)
- 13. Sensitivity-4: excluding patients with low vitamin D status (n = 15,924)
- 14. Sensitivity-5: excluding patients whose LOS ≥ 30 days (n = 742)
- 15. Sensitivity-6: excluding patients whose serum phosphate were not tested within 24 h (n = 3,330)
