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Table 2 Logistic regression of different concentrations of HDL-C and cognitive impairment

From: Very high high-density lipoprotein cholesterol may be associated with higher risk of cognitive impairment in older adults

HDL-C (mmol/L)

Events (n)

%

Crude

Model 1

Model 2

< 1.00

161/518

31.1

1.49 (1.17, 1.89)*

1.54 (1.16, 2.05)*

1.43 (1.06, 1.92)*

1.00-1.49

464/1850

25.1

1.10 (0.92, 1.33)

1.10 (0.89, 1.36)

1.04 (0.84, 1.30)

1.50–1.99

219/941

23.3

Reference

Reference

Reference

2.00-2.49

45/263

17.1

0.68 (0.48, 0.97)*

0.80 (0.54, 1.19)

0.87 (0.58, 1.30)

≥ 2.50

17/60

28.3

1.30 (0.73, 2.33)

1.90 (0.99, 3.66)

2.19 (1.12, 4.28)*

  1. Model 1: adjusted for age, sex, race, BMI and educational level;
  2. Model 2: adjusted for age, sex, race, BMI, educational level, physical activity, diabetes, smoking, alcohol consumption, lipid-lowering therapy, LDL cholesterol and triglycerides; *P < 0.05