Table 2 Blood chemistry levels of metabolic, β-cell function and obesity parameters
Outcomes | Follow-up period | Placebo (n = 115) | Curcumin (n = 114) | p value* | ||
|---|---|---|---|---|---|---|
Mean | Minimum-Maximum | Mean | Minimum-Maximum | |||
BMI (kg/m2) | 0 months | 26.94 | 16.45–35.18 | 27.35 | 20.40–36.58 | NS |
|  | 3 months | 26.98 | 16.88–40.37 | 26.56 | 19.15–44.81 | < 0.05 |
|  | 6 months | 26.96 | 17.31–40.79 | 25.90 | 18.31–43.71 | < 0.01 |
|  | 9 months | 27.00 | 16.88–40.79 | 25.96 | 19.14–42.61 | < 0.001 |
|  | 12 months | 27.34 | 17.72–42.11 | 25.98 | 17.90–42.24 | < 0.001 |
Body weight (kg) | 0 months | 69.50 | 61–112 | 69.92 | 71–120 | NS |
|  | 3 months | 69.53 | 62–113 | 67.72 | 70–117 | < 0.05 |
|  | 6 months | 69.47 | 63–119 | 66.06 | 69–135 | < 0.01 |
|  | 9 months | 69.01 | 63–117 | 66.08 | 68–117 | < 0.01 |
|  | 12 months | 69.30 | 63–140 | 66.10 | 68–114 | < 0.001 |
HbA1c (%) | 0 months | 6.26 | 4.80–8.90 | 6.28 | 4.40–9.50 | NS |
|  | 3 months | 6.44 | 5–8.90 | 6.26 | 4.70–9.20 | < 0.01 |
|  | 6 months | 6.46 | 5.10–9 | 6.25 | 4.50–8.30 | < 0.01 |
|  | 9 months | 6.47 | 5–10.40 | 6.19 | 4.10–8.20 | < 0.05 |
|  | 12 months | 6.47 | 5–10.50 | 6.12 | 4.20–8.40 | < 0.05 |
FPG (mg/dl) | 0 months | 125.08 | 91–285 | 123.65 | 79–178 | NS |
|  | 3 months | 128.93 | 100–195 | 124.40 | 80–171 | NS |
|  | 6 months | 130.34 | 77–231 | 122.82 | 79–204 | < 0.01 |
|  | 9 months | 130.93 | 97–201 | 118.67 | 75–165 | < 0.01 |
|  | 12 months | 130.71 | 98–194 | 115.49 | 70–160 | < 0.05 |
Insulin (uU/ml) | 0 months | 16.96 | 5.80–51.90 | 17.47 | 4.70–39 | NS |
|  | 3 months | 18.51 | 6.20–52.10 | 17.06 | 4.60–37.60 | < 0.05 |
|  | 6 months | 18.51 | 6.20–52.10 | 16.80 | 4.60–35.40 | < 0.05 |
|  | 9 months | 18.55 | 6.40–52.30 | 16.11 | 4.30–37.10 | < 0.05 |
|  | 12 months | 18.54 | 6.70–52.50 | 16.05 | 4–37 | < 0.01 |
HOMA-IR | 0 months | 5.24 | 1.70–21.80 | 5.38 | 1.20–14.20 | NS |
|  | 3 months | 5.88 | 2.00–17.00 | 5.25 | 1.70–12.80 | < 0.05 |
|  | 6 months | 5.93 | 1.80–17.90 | 5.17 | 1.60–16.50 | < 0.01 |
|  | 9 months | 6.02 | 2.20–19.80 | 5.02 | 1.30–11.50 | < 0.001 |
|  | 12 months | 6.04 | 2.30–18.00 | 4.86 | 1.20–11 | < 0.001 |
HOMA-β | 0 months | 108.44 | 13.50–359 | 113.26 | 25.60–456.80 | NS |
|  | 3 months | 108.56 | 30.20–313.80 | 113.83 | 19.30–412.90 | NS |
|  | 6 months | 109.19 | 23.60–408 | 114.53 | 20.20–427.50 | NS |
|  | 9 months | 108.32 | 23.70–310.20 | 123.73 | 24.20–546 | < 0.01 |
|  | 12 months | 105.19 | 29.40–275.30 | 136.20 | 25.30–915.40 | < 0.01 |
Adiponectin (ug/ml) | 0 months | 8.85 | 7.04–10.56 | 8.75 | 7.04–10.56 | NS |
|  | 3 months | 8.89 | 7.04–10.56 | 8.91 | 7.04–10.56 | NS |
|  | 6 months | 10.13 | 3.81–29.28 | 13.73 | 5.32–52.05 | < 0.01 |
|  | 9 months | 10.38 | 3.43–27.45 | 13.74 | 5.46–53.02 | < 0.001 |
|  | 12 months | 10.36 | 3.21–26.21 | 14.51 | 5.78–54.67 | < 0.001 |
Leptin (ug/ml) | 0 months | 13.38 | 7.04–19.36 | 13.84 | 7.04–19.36 | NS |
|  | 3 months | 13.28 | 7.04–55.59 | 13.47 | 7.04–19.36 | NS |
|  | 6 months | 20.41 | 3.56– 55.59 | 10.67 | 1.11–34.2 | < 0.001 |
|  | 9 months | 20.63 | 3.43–59.32 | 9.93 | 1.11–22.87 | < 0.001 |
|  | 12 months | 20.66 | 3.89–59.32 | 9.42 | 1.10-21.59 | < 0.001 |