Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial

Nutrition Journal

Table 2 Association of LFD scores with the risk of HNC and its subtypes

	No. of	No. of		Hazard ratio (95% confidence interval)
Quartiles of LFD score	Participants	Cases	Person-years	Unadjusted	Model 1^a	Model 2^b
HNC	98,459	268
Quartile 1 (≤ 10)	26,715	101	232483.5	1.00 (reference)	1.00 (reference)	1.00 (reference)
Quartile 2 (11–15)	26,151	69	229877.9	0.69 (0.51, 0.94)	0.71 (0.52, 0.96)	0.75 (0.56, 1.03)
Quartile 3 (16–20)	24,764	65	220840.0	0.68 (0.50, 0.92)	0.75 (0.55, 1.03)	0.85 (0.62, 1.16)
Quartile 4 (≥ 21)	20,829	33	188678.3	0.40 (0.27, 0.59)	0.51 (0.34, 0.75)	0.60 (0.40, 0.90)
P for trend				< 0.001	0.001	0.026
Oral Cavity and Pharynx cancer	98,352	161
Quartile 1 (≤ 10)	26,669	55	232261.3	1.00 (reference)	1.00 (reference)	1.00 (reference)
Quartile 2 (11–15)	26,127	45	229760.9	0.83 (0.56, 1.22)	0.84 (0.57, 1.24)	0.88 (0.59, 1.31)
Quartile 3 (16–20)	24,736	37	220692.6	0.71 (0.47, 1.07)	0.75 (0.49, 1.14)	0.82 (0.54, 1.25)
Quartile 4 (≥ 21)	20,820	24	188639.7	0.53 (0.33, 0.86)	0.62 (0.38, 1.00)	0.70 (0.43, 1.15)
P for trend				0.007	0.039	0.147
Larynx cancer	98,287	96
Quartile 1 (≤ 10)	26,660	46	232228.3	1.00 (reference)	1.00 (reference)	1.00 (reference)
Quartile 2 (11–15)	26,100	18	229634.0	0.40 (0.23, 0.68)	0.41 (0.24, 0.71)	0.45 (0.26, 0.78)
Quartile 3 (16–20)	24,722	23	220613.7	0.53 (0.32, 0.87)	0.62 (0.38, 1.03)	0.75 (0.45, 1.24)
Quartile 4 (≥ 21)	20,805	9	188546.9	0.24 (0.12, 0.49)	0.35 (0.17, 0.73)	0.46 (0.22, 0.96)
P for trend				< 0.001	0.003	0.039

a: Adjusted for age (years), sex (male, female) and race (white, non-white)
b: Adjusted for model 1 plus educational level (college below, college graduate, postgraduate), trial group (intervention, control), energy intake from diet (kcal/day), BMI (kg/m2), family history of HNC (no, yes, possibly), smoker (never, current or former), alcohol intake (no, yes), aspirin use (no, yes), history of hypertension (no, yes), history of diabetes (no, yes), and physical activity (min/week)

ISSN: 1475-2891