Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content

Table 3 Subgroup analyses on the association of LFD scores with the risk of HNC

From: Adherence to a low-fat dietary pattern reduces head and neck cancer risk: evidence from the PLCO trial

 

No. of

 

Hazard Ratio (95% Confidence Interval) by LFD Scores

  

Subgroup variable

Cases

Person-years

Quartile 1 (≤ 10)

Quartile 2 (11–15)

Quartile 3 (16–20)

Quartile 4 (≥ 21)

Ptrend

Pinteraction

Age (years)

       

0.227

≤ 65

121

455497.19

1.00 (reference)

0.533 (0.331, 0.858)

0.796 (0.498, 1.272)

0.588 (0.313, 1.103)

0.105

 

> 65

147

416382.43

1.00 (reference)

1.031 (0.679, 1.563)

0.969 (0.621, 1.512)

0.688 (0.398, 1.191)

0.242

 

Sex

       

0.467

Male

213

413369.39

1.00 (reference)

0.689 (0.487, 0.974)

0.869 (0.608, 1.241)

0.638 (0.395, 1.030)

0.103

 

Female

55

458510.2

1.00 (reference)

1.224 (0.601, 2.490)

0.945 (0.445, 2.004)

0.678 (0.294, 1.563)

0.296

 

Trial group

       

0.696

Intervention

133

427859.26

1.00 (reference)

0.875 (0.568, 1.349)

0.889 (0.561, 1.408)

0.596 (0.330, 1.076)

0.130

 

Control

135

444020.36

1.00 (reference)

0.672 (0.431, 1.048)

0.852 (0.543, 1.337)

0.662 (0.374, 1.173)

0.201

 

Energy intake from diet

       

0.705

<=median

96

436424.28

1.00 (reference)

0.856 (0.491, 1.492)

0.810 (0.466, 1.409)

0.675 (0.370, 1.231)

0.227

 

> median

172

435455.3

1.00 (reference)

0.734 (0.506, 1.065)

0.943 (0.637, 1.394)

0.566 (0.311, 1.030)

0.144

 

BMI (kg/m2)

       

0.480

≤ 30

215

678412.9

1.00 (reference)

0.784 (0.556, 1.104)

0.816 (0.566, 1.177)

0.688 (0.441, 1.073)

0.123

 

> 30

53

193466.71

1.00 (reference)

0.704 (0.349, 1.420)

1.108 (0.563, 2.180)

0.424 (0.141, 1.276)

0.344

 

Alcohol intake

       

0.871

No

60

234366.13

1.00 (reference)

0.717 (0.350, 1.469)

0.923 (0.467, 1.823)

0.742 (0.345, 1.599)

0.595

 

Yes

208

637513.5

1.00 (reference)

0.784 (0.557, 1.104)

0.858 (0.595, 1.237)

0.576 (0.351, 0.947)

0.049

 

Family history of HNC

       

0.175

No

251

837764.70

1.00 (reference)

0.771 (0.566, 1.05)

0.847 (0.616, 1.165)

0.573 (0.379, 0.867)

0.043

 

Yes/possibly

17

34114.92

1.00 (reference)

0 (0, Inf)

0.546 (0.051, 5.892)

2.902 (0.331, 25.428)

0.991

 

Smoker

       

0.607

Never

62

424544.34

1.00 (reference)

1.037 (0.531, 2.022)

0.847 (0.418, 1.714)

0.672 (0.304, 1.489)

0.278

 

Current or former

206

447335.28

1.00 (reference)

0.709 (0.499, 1.008)

0.904 (0.629, 1.299)

0.630 (0.387, 1.027)

0.120

 

Aspirin use

       

< 0.001

No

123

466406.80

1.00 (reference)

0.406 (0.244, 0.675)

0.915 (0.595, 1.406)

0.292 (0.130, 0.652)

0.017

 

Yes

145

405472.82

1.00 (reference)

1.257 (0.828, 1.909)

0.862 (0.530, 1.403)

0.991 (0.591, 1.660)

0.630

 

History of hypertension

       

0.130

No

183

594960.31

1.00 (reference)

0.740 (0.506, 1.083)

1.068 (0.734, 1.553)

0.601 (0.354, 1.020)

0.266

 

Yes

85

276919.32

1.00 (reference)

0.827 (0.488, 1.402)

0.516 (0.272, 0.980)

0.660 (0.342, 1.276)

0.075

 

History of diabetes

       

0.997

No

252

818456.1

1.00 (reference)

0.774 (0.564, 1.064)

0.875 (0.628, 1.219)

0.641 (0.420, 0.980)

0.070

 

Yes

16

53423.56

1.00 (reference)

0.648 (0.180, 2.327)

0.767 (0.207, 2.836)

0.475 (0.090, 2.514)

0.424

 

Physical activity

       

0.099

<=median

159

440583.91

1.00 (reference)

1.059 (0.723, 1.551)

1.000 (0.650, 1.538)

0.739 (0.417, 1.312)

0.436

 

> median

109

431295.72

1.00 (reference)

0.437 (0.256, 0.747)

0.692 (0.427, 1.119)

0.479 (0.266, 0.863)

0.033

 
  1. HRs were adjusted for age (years), sex (male, female) and race (white, non-white), educational level (college below, college graduate, postgraduate), trial group (intervention, control), energy intake from diet (kcal/day), BMI (kg/m2), smoker (never, current or former), alcohol intake (no, yes), family history of HNC (no, yes/possibly), aspirin use (no, yes), history of hypertension (no, yes), history of diabetes (no, yes), and physical activity (min/week)
Back to article page

Nutrition Journal

ISSN: 1475-2891

Contact us