Table 2 Multivariate Cox regression derived HRs and 95% CIs for all-cause mortality and cause-specific mortality by essential amino acid intakes

Median intake (g/day)

26.30

16.90

22.27

26.31

30.86

39.05

All-cause mortality

Number of deaths

9,231

2,093

1,797

1,634

1,734

1,973

Model 1

1.16 (1.08–1.25)

1.07 (1.00-1.14)

Ref

1.03 (0.96–1.10)

1.18 (1.10–1.27)

< 0.001

Model 2

1.16 (1.07–1.26)

1.08 (1.00-1.16)

Ref

1.02 (0.95–1.10)

1.06 (0.97–1.17)

< 0.001

Cardiovascular mortality

Number of deaths

4,215

978

792

718

808

919

Model 1

1.15 (1.03–1.28)

1.04 (0.94–1.15)

Ref

1.11 (1.00-1.23)

1.32 (1.18–1.46)

< 0.001

Model 2

1.23 (1.09–1.38)

1.10 (0.99–1.23)

Ref

1.09 (0.95–1.21)

1.09 (0.95–1.25)

0.003

Cancer mortality

Number of deaths

1,887

398

401

342

357

389

Model 1

1.30 (1.11–1.53)

1.23 (1.06–1.43)

Ref

0.95 (0.82–1.11)

0.93 (0.79–1.09)

0.241

Model 2

1.17 (0.98–1.41)

1.14 (0.98–1.33)

Ref

0.97 (0.83–1.14)

1.03 (0.83–1.27)

0.174

Other mortality

Number of deaths

3,373

772

662

614

614

711

Model 1

1.10 (0.98–1.24)

1.04 (0.93–1.16)

Ref

0.98 (0.87–1.10)

1.17 (1.04–1.32)

< 0.001

Model 2

1.06 (0.93–1.21)

1.02 (0.91–1.15)

Ref

0.99 (0.87–1.11)

1.08 (0.92–1.26)

0.083