Table 3 Multivariate Cox regression derived HRs and 95% CIs for all-cause mortality and cause specific mortality by non-essential amino acids intake

Median intake (g/day)

44.56

29.07

38.21

44.58

51.29

63.54

All-cause mortality

Number of deaths

9,231

2,144

1,745

1,674

1,703

1,965

Model 1

1.12 (1.04–1.21)

1.01 (0.94–1.08)

Ref

1.04 (0.97–1.11)

1.20 (1.12–1.30)

< 0.001

Model 2

1.16 (1.06–1.26)

1.03 (0.95–1.10)

Ref

1.02 (0.95–1.09)

1.06 (0.96–1.16)

< 0.001

Cardiovascular mortality

Number of deaths

4,215

981

771

762

795

906

Model 1

1.01 (0.90–1.13)

0.94 (0.85–1.04)

Ref

1.10 (0.99–1.22)

1.34 (1.20–1.50)

< 0.001

Model 2

1.14 (1.01–1.29)

0.99 (0.89–1.11)

Ref

1.05 (0.94–1.17)

1.05 (0.91–1.21)

0.016

Cancer mortality

Number of deaths

1,887

412

376

371

329

399

Model 1

1.28 (1.09–1.51)

1.08 (0.94–1.26)

Ref

0.82 (0.71–0.96)

0.85 (0.71-1.00)

0.126

Model 2

1.18 (0.98–1.42)

1.08 (0.92–1.26)

Ref

0.86 (0.73–1.01)

0.93 (0.75–1.15)

0.185

Other mortality

Number of deaths

3,373

808

653

582

628

702

Model 1

1.19 (1.05–1.34)

1.07 (0.96–1.21)

Ref

1.11 (0.99–1.24)

1.27 (1.12–1.45)

< 0.001

Model 2

1.16 (1.01–1.33)

1.06 (0.94–1.19)

Ref

1.09 (0.96–1.23)

1.15 (0.97–1.34)

0.005