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Table 5 Multivariate Cox regression derived HRs and 95% CIs for all-cause mortality and cause specific mortality by AAAs intake

From: Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study

AAAs

Total

(n = 47,337)

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P for Non-linearity

Median intake (g/day)

6.52

4.24

5.56

6.52

7.56

9.44

All-cause mortality

Number of deaths

9,231

2,147

1,745

1,647

1,733

1,959

Model 1

1.18 (1.10–1.27)

1.05 (0.98–1.12)

Ref

1.05 (0.98–1.12)

1.19 (1.10–1.28)

< 0.001

Model 2

1.19 (1.09–1.29)

1.05 (0.97–1.13)

Ref

1.03 (0.96–1.11)

1.05 (0.95–1.15)

< 0.001

Cardiovascular mortality

Number of deaths

4,215

992

777

745

787

914

Model 1

1.10 (0.99–1.23)

1.00 (0.90–1.10)

Ref

1.08 (0.98–1.20)

1.32 (1.18–1.47)

< 0.001

Model 2

1.21 (1.07–1.36)

1.04 (0.94-1.16)

Ref

1.05 (0.94–1.17)

1.05 (0.91–1.21)

0.004

Cancer mortality

Number of deaths

1,887

422

372

347

350

396

Model 1

1.42 (1.21–1.67)

1.16 (1.00-1.35)

Ref

0.92 (0.79–1.07)

0.90 (0.76–1.06)

0.026

Model 2

1.28 (1.07–1.54)

1.10 (0.94–1.29)

Ref

0.95 (0.81–1.11)

0.97 (0.78–1.19)

0.052

Other mortality

Number of deaths

3,373

790

655

594

640

694

Model 1

1.17 (1.03–1.32)

1.08 (0.96–1.21)

Ref

1.09 (0.97–1.22)

1.21 (1.07–1.37)

< 0.001

Model 2

1.11 (0.96–1.27)

1.05 (0.93–1.18)

Ref

1.06 (0.94–1.20)

1.1 (0.94–1.28)

0.058

  1. Significant values are in bold
  2. Model 1: Adjusted for age, sex and intake of energy
  3. Model 2: Adjusted for age, sex, intake of energy, BMI, cigarette smoking, opium use, diabetes, hypertension, alcohol use, wealth index, education, physical activity, total lipid intake, and total protein intake
  4. Abbreviations: AAAs, aromatic amino acids; BMI, body mass index; CI, confidence interval; HR, hazard ratio; Ref, reference