Skip to main content

Table 6 Multivariate Cox regression derived HRs and 95% CIs for all-cause mortality and cause specific mortality by SAAs intake

From: Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study

SAAs

Total

(n = 47,337)

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P for Non-linearity

Median intake (g/day)

2.70

1.75

2.30

2.70

3.14

3.96

All-cause mortality

Number of deaths

9,231

2,134

1,731

1,678

1,711

1,977

Model 1

1.15 (1.07–1.24)

1.01 (0.94–1.08)

Ref

1.02 (0.94–1.08)

1.19 (1.10–1.28)

< 0.001

Model 2

1.18 (1.09–1.28)

1.02 (0.95–1.10)

Ref

1.00 (0.95–1.08)

1.04 (0.95–1.14)

< 0.001

Cardiovascular mortality

Number of deaths

4,215

977

761

754

800

923

Model 1

1.06 (0.95–1.18)

0.95 (0.86–1.05)

Ref

1.09 (0.98–1.20)

1.33 (1.19–1.48)

< 0.001

Model 2

1.17 (1.03–1.32)

0.99 (0.89–1.11)

Ref

1.05 (0.94–1.16)

1.07 (0.93–1.22)

0.003

Cancer mortality

Number of deaths

1,887

420

368

366

333

400

Model 1

1.32 (1.13–1.55)

1.07 (0.92–1.24)

Ref

0.84 (0.72–0.98)

0.89 (0.76–1.05)

0.023

Model 2

1.21 (1.01–1.45)

1.04 (0.89–1.21)

Ref

0.87 (0.74–1.02)

0.97 (0.79–1.19)

0.036

Other mortality

Number of deaths

3,373

792

657

598

628

698

Model 1

1.17 (1.04–1.32)

1.07 (0.95–1.19)

Ref

1.05 (0.94–1.18)

1.20 (1.07–1.36)

< 0.001

Model 2

1.18 (1.03–1.35)

1.08 (0.95–1.21)

Ref

1.05 (0.93–1.18)

1.06 (0.91–1.24)

0.032

  1. Significant values are in bold
  2. Model 1: Adjusted for age, sex and intake of energy
  3. Model 2: Adjusted for age, sex, intake of energy, BMI, cigarette smoking, opium use, diabetes, hypertension, alcohol use, wealth index, education, physical activity, total lipid intake, and total protein intake
  4. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; Ref, reference; SAAs, sulfur-containing amino acids