Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality

Nutrition Journal

Table 2 Results of bidirectional MR analysis of 25OHD and MS

Exposure	Outcome	Methods	Estimate	P	Heterogeneity test
Exposure	Outcome	Methods	Estimate	P	Estimate	P
25OHD	MS	IVW (fixed)	0.733 (0.638, 0.843)	1.31E-05	153.087	0.005
		IVW (random)	0.733 (0.622, 0.864)	2.07E-04
		MR-Egger (slope)	0.774 (0.614, 0.975)	0.030
		MR-Egger (intercept)	-0.002 (-0.008, 0.004)	0.508
		Weighted mode	0.739 (0.631, 0.865)	1.70E-04
		Weighted median	0.785 (0.633, 0.973)	0.027
		DIVW	0.732 (0.617, 0.867)	3.24E-04
		MR-RAPS	0.738 (0.627, 0.869)	2.64E-04
MS	25OHD	IVW (fixed)	0.999 (0.995, 1.003)	0.679	113.751	< 0.001
		IVW (random)	0.999 (0.994, 1.005)	0.760
		MR-Egger (slope)	1.012 (0.996, 1.028)	0.143
		MR-Egger (intercept)	-0.002 (-0.004, 0)	0.094
		Weighted mode	1.001 (0.987, 1.016)	0.859
		Weighted median	0.998 (0.992, 1.005)	0.604
		DIVW	0.999 (0.994, 1.005)	0.755
		MR-RAPS	0.999 (0.993, 1.004)	0.658

ISSN: 1475-2891