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Table 2 Certainty of evidence table

From: The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review

Certainty assessment

Summary of findings

Outcomes

Risk of biasa

Indirectness

Inconsistency

Imprecisionb

Publication bias

GRADE

Relative effect (95%CI)

Number of participants (studies)

Plant-rich diets

 BMI

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-0.09 (-0.24, 0.06)

283 (3)

 Weight

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-0.45 (-0.77, -0.13)

432 (7)

 Waist

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-0.70 (-1.42, 0.01)

401 (6)

 SBP

-1

0

0

-1

0

⊕⊕○○ Low certainty evidence

-1.69 (-3.91, 0.54)

231 (5)

 DBP

-1

0

0

-1

0

⊕⊕○○ Low certainty evidence

-0.49 (-2.34, 1.36)

231 (5)

 Glucose

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-0.24 (-3.06, 2.58)

389 (6)

 TC

0

0

0

0

0

⊕⊕⊕⊕ High certainty evidence

-6.77 (-12.36, -1.18)

420 (7)

 HDL-C

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-0.02 (-1.81, 1.78)

420 (7)

 LDL-C

0

0

0

0

0

⊕⊕⊕⊕ High certainty evidence

-4.37 (-7.59, -1.16)

420 (7)

 TG

0

0

0

-1

0

⊕⊕⊕○ Moderate certainty evidence

-5.90 (-14.38, 2.57)

420 (7)

Restrictive diets

 BMI

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-1.59 (-2.18, -0.99)

475 (5)

 Weight

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-4.02 (-5.26, -2.77)

475 (5)

 Waist

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-4.25 (-5.52, -2.98)

475 (5)

 SBP

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-4.01 (-8.74, 0.71)

475 (5)

 DBP

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-2.68 (-6.18, 0.81)

475 (5)

 Glucose

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-7.13 (-12.01, -2.25)

485 (6)

 TC

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-8.74 (-12.72, -4.76)

485 (6)

 HDL-C

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-0.24 (-2.00, 1.52)

485 (6)

 LDL-C

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-1.14 (-5.99, 3.71)

485 (6)

 TG

-1

0

-1

0

0

⊕⊕○○ Low certainty evidence

-22.12 (-36.05, -8.19)

485 (6)

  1. Abbreviation: BMI body mass index, CVD cardiovascular disease, DBP diastolic blood pressure, HDL-C high-density lipoprotein, LDL-C low density lipoprotein, SBP systolic blood pressure, TC total cholesterol, TG triglyceride
  2. aDowngrade by one or two level if the included studies were at high risk of bias
  3. bDowngrade by one level if the sample size did not meet the optimal information size criterion or if it is less than 400