Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES

Table 2 Association of PA and 25(OH)D with mortality in US stroke survivors aged 70 years and younger, NHANES, 2007 to 2018

Mortality outcome	Adjusted model 1	P value	Adjusted model 2	P value	Adjusted model 3	P value
	HR (95%CI)		HR (95%CI)		HR (95%CI)
All causes
25(OH)D	0.988(0.977,0.999)	0.026	0.984(0.975,0.994)	0.001	0.984(0.974,0.993)	0.001
25(OH)D
Lower	1 (Ref)		1(Ref)		1(Ref)
Higher	0.466(0.279,0.779)	0.004	0.392(0.248,0.617)	< 0.001	0.376(0.233,0.607)	< 0.001
PA
No	1 (Ref)		1(Ref)		1(Ref)
Yes	0.242(0.098,0.594)	0.002	0.280(0.106,0.738)	0.010	0.280(0.107,0.733)	0.01
MACE
25(OH)D	0.998(0.981,1.015)	0.799	0.998(0.983,1.013)	0.750	1.000(0.984,1.016)	0.989
25(OH)D
Lower	1 (Ref)		1(Ref)		1(Ref)
Higher	0.773(0.316,1.889)	0.573	0.794(0.315,2.000)	0.624	0.934(0.383,2.281)	0.882
PA
No	1 (Ref)		1(Ref)		1(Ref)
Yes	0.187(0.038,0.922)	0.039	0.312(0.062,1.571)	0.158	0.309(0.063,1.527)	0.150
Non-MACE
25(OH)D	0.983(0.970,0.997)	0.017	0.978(0.966,0.991)	< 0.001	0.977(0.965,0.988)	< 0.001
25(OH)D
Lower	1 (Ref)		1(Ref)		1(Ref)
Higher	0.383(0.202,0.727)	0.003	0.295(0.168,0.518)	< 0.001	0.265(0.143,0.490)	< 0.001
PA
No	1 (Ref)		1(Ref)		1(Ref)
Yes	0.268(0.093,0.768)	0.014	0.262(0.083,0.828)	0.023	0.266(0.087,0.810)	0.02

Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, race, body mass index, education, history of smoking and drinking. Model 3 adjusted for age, sex, race, body mass index, education, history of smoking and drinking, and health factors (hypertension, dyslipidemia, diabetes, CVD)

ISSN: 1475-2891