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Table 3 Relationship between ASMI, sarcopenia and hepatic fibrosis in patients with MASLD in the Chinese cohort

From: Correlation of sarcopenia with progression of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: a study from two cohorts in China and the United States

Variables

Model 1

Model 2

Model 3

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

Significant fibrosis

 ASMI

0.40 (0.25 ~ 0.64)

< 0.001

0.07 (0.03 ~ 0.15)

< 0.001

0.26 (0.12 ~ 0.59)

0.001

  Categories

   Quartile 1

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Quartile 2

0.94 (0.77 ~ 1.15)

0.577

0.61 (0.47 ~ 0.79)

< 0.001

0.75 (0.57 ~ 0.99)

0.040

   Quartile 3

0.95 (0.78 ~ 1.16)

0.648

0.50 (0.37 ~ 0.68)

< 0.001

0.68 (0.49 ~ 0.94)

0.019

   Quartile 4

0.65 (0.53 ~ 0.79)

< 0.001

0.33 (0.24 ~ 0.46)

< 0.001

0.54 (0.38 ~ 0.76)

< 0.001

  Sarcopenia

   No

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Yes

1.59 (1.33 ~ 1.90)

< 0.001

1.59 (1.33 ~ 1.91)

< 0.001

1.27 (1.04 ~ 1.54)

0.018

Advanced fibrosis

 ASMI

0.34 (0.19 ~ 0.62)

< 0.001

0.07 (0.03 ~ 0.19)

< 0.001

0.25 (0.09 ~ 0.69)

0.007

  Categories

   Quartile 1

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Quartile 2

0.88 (0.69 ~ 1.12)

0.289

0.58 (0.42 ~ 0.80)

0.001

0.69 (0.49 ~ 0.97)

0.032

   Quartile 3

0.88 (0.69 ~ 1.12)

0.289

0.48 (0.33 ~ 0.71)

< 0.001

0.63 (0.42 ~ 0.94)

0.023

   Quartile 4

0.59 (0.46 ~ 0.77)

< 0.001

0.32 (0.22 ~ 0.48)

< 0.001

0.51 (0.33 ~ 0.77)

0.002

  Sarcopenia

   No

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Yes

1.55 (1.25 ~ 1.93)

< 0.001

1.58 (1.27 ~ 1.97)

< 0.001

1.27 (1.01 ~ 1.60)

0.047

Cirrhosis

 ASMI

0.31 (0.13 ~ 0.75)

0.009

0.03 (0.01 ~ 0.12)

< 0.001

0.13 (0.03 ~ 0.57)

0.007

  Categories

   Quartile 1

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Quartile 2

1.02 (0.71 ~ 1.45)

0.928

0.57 (0.35 ~ 0.92)

0.022

0.69 (0.42 ~ 1.14)

0.152

   Quartile 3

0.92 (0.64 ~ 1.32)

0.642

0.41 (0.24 ~ 0.71)

0.002

0.56 (0.31 ~ 0.99)

0.048

   Quartile 4

0.58 (0.39 ~ 0.87)

0.009

0.26 (0.14 ~ 0.47)

< 0.001

0.44 (0.24 ~ 0.83)

0.010

  Sarcopenia

   No

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

   Yes

1.75 (1.29 ~ 2.38)

< 0.001

1.73 (1.26 ~ 2.36)

< 0.001

1.65 (1.19 ~ 2.28)

0.002

  1. Model 1: crude
  2. Model 2: adjusted for Gender, Age
  3. Model 3: adjusted for Gender, Age, Smoke, Alcohol, Physical Activity, Diabetes mellitus, Hypertension
  4. Abbreviations: ASMI Appendicular skeletal muscle mass index, MASLD Metabolic dysfunction-associated steatotic liver disease, OR  Odds ratio, CI Confidence interval
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Nutrition Journal

ISSN: 1475-2891

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