An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition

Table 3 Cox regression analysis of CK prognostic value in male pancreatic cancer patients

Parameter	OS				DFS
	Univariate analyses	Multivariate analyses			Univariate analyses	Multivariate analyses
	P value	HR	95% CI	P value	P value	HR	95% CI	P value
Age, years	0.833				0.219
Back pain	0.022	NA	NA	0.087	0.101
Loss of weight	0.863				0.825
BMI, kg/m²	0.280				0.149
Albumin, g/L	0.665				0.422
TNM Stage, vs. Stage I
Stage II	0.053	2.930	1.305, 6.579	0.009	0.015	NA	NA	0.522
Stage III	0.001	3.407	1.511, 7.681	0.003	0.001	NA	NA	0.901
Tumor location, body or tail (vs. head or neck)	0.926				0.938
Differentiation of tumor, vs. poor
Moderate	0.236				0.542
Well	0.949				0.362
Vascular invasion	0.052	NA	NA	0.826	0.004	2.116	1.241, 3.609	0.006
Lymphatic invasion	0.371				0.014	1.729	1.033, 2.892	0.037
Margin, R0 resection	0.702				0.680
Chemotherapy	0.001	0.166	0.076, 0.363	<0.001	0.334
CK>44 IU/L	0.015	0.226	0.107, 0.478	<0.001	0.011	0.272	0.139, 0.529	< 0.001
CA199, U/mL	0.007	1.001	1.000, 1.002	0.003	0.161

BMI: body mass index; CK: creatine kinase; OS: overall survival; DFS: disease free survival; HR: hazard ratio; CI: confidence interval. Boldface indicates P < 0.05

ISSN: 1475-2891