Fig. 2

Mediation analysis on the causal association between sugar sweetened beverages and breast cancer using two-step Mendelian randomization. Abbreviations: CI, confidence interval; OR, odds ratio; LDL, low-density lipoprotein; HDL-C, high-density lipoprotein cholesterol; TFAs, total fatty acids. .^aThe β/OR and 95% CI were estimated using two-sample univariable Mendelian randomization analysis, with inverse-variance weighted as the main method. *P < 0.05; **P < 0.01